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Lesley H. Greene




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Department of Chemistry & Biochemistry




Select Publications

1.       L.H. Greene, H. Li, J. Zhong, G. Zhao and K. Wilson (2011) Folding of an all-helical Greek-key protein monitored by quenched-flow hydrogen-deuterium exchange and NMR spectroscopy. Submitted.

2.       E. Karakas, A. Munyanyi, L. Greene and M. Laroussi (2010) Destruction of a-synuclein based amyloid fibrils by a low temperature plasma jet. Applied Physics Letters, 97, 143702.

3.       H. Li and L.H. Greene (2010) Sequence and structural analysis of the chitinase insertion domain reveals two conserved motifs involved in chitin-binding. PLoS ONE, 13, e8654.

4.       V.A. Higman, H.I. Rosner, R. Ugolini, L.H. Greene, C. Redfield and L.J. Smith (2009) Probing the urea dependence of nonrandom interactions in denatured human a-lactalbumin. J. Biomolecular NMR, 45, 121-131.

5.       A. Cuff, O.C. Redfern, L.H. Greene, I. Sillitoe, T. Lewis, M. Dibley, A. Reid, F. Pearl, T. Dallman, A. Todd, R. Garratt, J. Thornton and C. Orengo (2009) The CATH hierarchy revisited - structural divergence in domain superfamilies and the continuity of fold space. Structure, 17, 1051-1062.

6.       H. Li, J. Wojtaszek and L.H. Greene (2009) Analysis of conservation in the Fas-associated death domain protein and the importance of conserved tryptophans in structure, stability and folding. Biochimica et Biophysica Acta - Proteins & Proteomics, 1794, 583-593.

7.       L.H. Greene, T.E. Lewis, S. Addou, A. Cuff, T. Dallman, M. Dibley, O. Redfern, F. Pearl, R. Nambudiry, A. Reid, I. Sillitoe, C. Yeats, J.M. Thornton and C.A. Orengo (2007) The CATH domain structure database: new protocols and classification levels give a more comprehensive resource for exploring evolution.  Nucleic Acids Research, 35, D291-D297.

8.       L.H. Greene, R. Wijesinha-Bettoni and C. Redfield  (2006)  Characterization of the molten globule of human-serum retinol-binding protein by NMR spectroscopy.  Biochemistry, 45, 9475-9484.

9.       V.A. Higman and L.H. Greene (2006) Elucidation of conserved long-range interaction networks in proteins and their significance in determining protein topology.  Physica A: Statistical mechanics and its applications, 368, 595-606.

10.    E. Paci, L.H. Greene, R.M. Jones and L.J. Smith (2005) Characterization of the molten globule state of retinol-binding protein using a molecular dynamics simulation approach. FEBS J., 272, 4826-4838.

11.    M. Neerathilingam, L.H. Greene, S.A. Colebrooke, I.D. Campbell and D. Staunton (2005) Quantitation of protein expression in a cell-free system: Efficient detection of yields and 19F NMR to identify folded protein. J. Biomolecular NMR, 31, 11-19.

12.    L.H. Greene and V.A. Higman (2005) Conserved networks and the determinants of protein topology. FEBS J., 272, Suppl. 1.

13.    L. Gaforina, D. Sanchez, L.H. Greene and D.R. Flower. The lipocalin protein family: Protein sequence and structure. In: Lipocalins, Edited by Akerstrom, Borregard, Flowers and Salier. Georgetown, TX. Landes Biosciences and Eurekha.com  (Book chapter, 2006).

14.    L.H. Greene (2004) Investigating protein folding, misfolding and nonnative states: Experimental and theoretical methods (Editorial). Methods, 34, 1-3. This issue contained 13 articles written by experts from the USA, Canada, U.K., Japan and Germany.

15.    L.H. Greene and V.A. Higman. (2003) Uncovering network systems within protein structures. Journal of Molecular Biology, 334, 781-791.

16.    L.H. Greene, D. Hamada, S.J. Eyles and K. Brew (2003) Conserved signature proposed for folding in the lipocalin superfamily. FEBS Letters, 553, 39-44.

17.    M.G. McCammon, D.J. Scott, C.A. Keetch, L.H. Greene, H.E. Purkey, H.M. Petrassi, J.W. Kelly and C.V. Robinson (2002) Screening transthyretin amyloid fibril inhibitors - Characterization of novel multi-protein, multi-ligand complexes by mass spectroscopy. Structure, Folding and Design, 10, 851-863.

18.    L.H. Greene, E.D. Chrysina, L.I. Irons, A.C. Papageorgiou, K.R. Acharya and K. Brew (2001) Role of conserved residues in structure and stability: tryptophans of human serum retinol-binding protein. Protein Science, 10, 2301-2316.

19.    L.H. Greene, J.A.Grobler, V.A. Malinovskii, J. Tian, K.R. Acharya and K. Brew. (1999) Stability, activity, and flexibility in a-lactalbumin. Protein Engineering, 12, 581-587.

20.    K.H. Roux, A.S. Greenberg, L. Greene, L. Strelets, D. Avila, E.C. McKinney and M.F. Flajnik. (1998) Structural analysis of the nurse shark (new) antigen receptor (NAR): Molecular convergence of NAR and unusual mammalian immunoglobulins. Proc. Natl. Acad. Science, USA, 95, 11804-11809.

21.    K. Brew and L. Greene (1997) Evolution, folding and flexibility. Protein Engineering, 10, suppl. 44.

22.    L. Greene and K. Brew (1995) Conserved residues in the lipocalins suggest a folding motif. Protein Engineering, 8, suppl. 100.

 

Select Talks and Communications

1)       Oral presentation: American Chemical Society National Conference, Denver, CO (August 2011).

2)      Poster presentation: 25th Anniversary Symposium of the Protein Society, Boston, MA (July 2011).

3)      Invited talk: 20th International Symposium on Plasma Chemistry, Philadelphia, PA (July 2011).

4)      Invited lecture: Institute of Environmental Health Sciences, Wayne State University, MI (April 2011).

5)      Invited talk: NextMed/Medicine Meets Virtual Reality (MMVR18), Orange County, CA (February 2011).

6)      Oral presentation: 37th IEEE International Conference on Plasma Science, Norfolk, VA (June 2010).

7)      Invited lecture: Department of Chemistry and Biochemistry, University of North Carolina, Wilmington, N.C. (November 2010).

8)      Oral presentation: 238th American Chemical Society National Conference, Washington D.C., (August 2009).

9)      Invited lecture: Department of Chemistry, Winthrop University, S.C. (April 2009).

10)   Invited lecture: Department of Chemistry, Shippensburg University, PA (October 2008).

11)    Invited lecture: Department of Biochemistry, Eastern Virginia Medical School, VA (April 2008).

12)   Invited lecture: Department of Chemistry, Washington and Lee University, VA (March 2008).

13)   Invited lecture: Randolph-Macon University, VA (October 2008).

14)   Invited lecture: Department of Chemistry, Hampton University, VA (October 2008).

15)   Invited lecture: Department of Chemistry and Biochemistry, George Mason University, VA (April 2007).

16)   Invited lecture: Department of Computer Science, Norfolk State University, VA (April 2007).

17)   Invited lecture: 'Bioinformatics to Proteomics' Course, Birkbeck College-University of London, London, UK (September 2006).

18)   Poster presentation: 30th FEBS Congress and 9th IUBMB Conference on Proteins. Budapest, Hungary (July 2005).

19)   Invited talk: The Lipocalin Family - Benzon Symposium #50. Copenhagen,

Denmark (August 2003).

20) Invited talk: Genomics, Proteomics and Bioinformatics for Medicine. St. Petersburg, Russia (July 2002).

21) Poster presentation: 4th International Conference on Molecular Structural Biology. Vienna, Austria (September 2001).

22) Poster presentation: NMR in Molecular Biology. From Structure to Function - Folding, Catalysis, Interaction and Signalling. Copenhagen, Denmark (June 2001).

23) Poster presentation: XIX International Conference on Magnetic Resonance in Biological System. Florence, Italy (August 2000).

24) Invited talk: Department of Biochemistry, University of Florence, Florence, Italy (August 2000).

25) Poster presentation: 18th International Congress of Biochemistry and Molecular Biology. Birmingham, U.K. (July 2000).



Contact Information

Email Lesley H. Greene

Phone Numbers:
Office: 757.683.6596
Laboratory: 757.683.4086
Fax: 757.683.4628

Location:
Office: Alfriend Chemistry Building Room 202
Laboratory: Alfriend Chemistry Building Rooms 205 and 209





Office Hours

Monday and Wednesday 3pm - 4pm

Other times by appointment





What We Do

Current Publications





Who We Are

Dr. Lesley H. Greene

Current Group Members

Greene Lab Alumni





Where We Work

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